This work demonstrates a new analytical technique and its quantification capabilities on disparate metal samples. The laser ablation laser ionization time-of-flight mass spectrometer (LALI-TOF-MS) combines a dual-laser ionization system with a TOF mass analyzer for rapid, high-sensitivity elemental characterization of any solid material. Nine different reference materials were analyzed to demonstrate the instrument’s quantification capabilities. One solid and one powder reference material were then treated as “unknowns,” and quantified using calibration curves generated from the remaining reference materials. Despite being generated from reference materials of various matrices, elemental calibration curves are linear with an average R2 value of 0.96, even for elements that span several orders of magnitude in the concentration range. For all elements quantified, results match the certified values of the “unknown” within the margins of error.